What is migraine?
Migraine is a chronic and recurring pathology that affects 15% of the population, it is more prevalent in women. It reduces well-being from people’s quality of life and can be very disabling.
Migraine attacks can last hours or days and may be accompanied by auras or warning symptoms such as visual disturbances or tingling in the face or extremities.
Different scientific studies place diet and especially the ability to metabolize histamine intake as one of the main risk factors for migraine.
What is DAO?
Histamine is a biogenic amine present in a large number of foods. We speak of histamine intolerance when there is an imbalance between the accumulated histamine and its degradation capacity.
Diamino oxidase (DAO) is the most important enzyme in the metabolization of histamine, so a decrease in its activity translates into an increased risk of suffering the adverse effects of histamine intolerance, notable for its incapacitating nature. migraine.
The intake of histamine-risk foods (citrus fruits, chocolate, spinach, raspberries, walnuts, tomatoes, pineapple…), alcohol or drugs that release histamine or block DAO can cause migraine, asthma, hypotension, arrhythmia or urticaria.
Main causes of decreased DAO activity
Ο Genetics
Individuals carrying the rs10156191, rs1049742 or rs1049793 polymorphisms in the AOC1 gene have lower DAO activity than non-carrier individuals.
Ο Inflammatory bowel diseases
Such as Ulcerative Colitis, Crohn’s disease and irritable bowel syndrome.
Ο Pharmacological
There is a wide spectrum of drugs with the capacity to release histamine or inhibit the activity of DAO: Acetylcysteine, Acetylsalicylic acid, Clavulamic acid, Alprenolol, Amiloride, Amitriptyline, Cefuroxime, Cimetidine, Chloroquine, Dolbutamine, Meroclopramide, Pancuronium Propafenone…
Process
DELIVERY TIME: 12 WORKING DAYS.
Extraction of 1 mL of blood into frozen serum.
Receipt and analysis of the sample in our laboratory.
Sending the report in 12 business days.
For further clarification, your doctor will explain the results to you.
PRIOR PREPARATION
- Carry out the blood draw 24-72 hours after a migraine attack.
- 8 hours of fasting.
- Discontinue antihistamine treatment 15 days before, under medical supervision.
This test cannot be performed during pregnancy.
How does it work?
Choose to take care of yourself.
Pay securely.
Go to a Cerba center.
Check your results online.
